In vitro experiment reveals that the combined photothermal and chemo-therapy exhibits much higher toxicity to 4T1 cells than photothermal therapy or chemotherapy alone.
While carcinogenicity of the active ingredient remains a matter of debate [82], it is documented that additives and their mixtures used in the commercial formulations for spraying glyphosate show a much higher toxicity than the active ingredient alone [83].
It's a stimulant with similar effects to MDMA but with much higher toxicity levels.
It's a stimulant with similar effects to MMA but with much higher toxicity levels.
This metal exhibits much higher toxicity to microorganisms than to mammalian cells.
Our study of CY as a prototype of DNA/HDAC dual-targeting drug demonstrates that by incorporating HDAC inhibitory moiety into traditional DNA-damaging drugs, it is indeed possible to achieve much higher toxicity against cancer cells.
In line with these results, INZ displayed much higher toxicity to p53-containing human cancer cells compared with WI-38 and NHF, or p53-mutant and null cancer cells.
For example, the combination of bevacizumab and temsirolimus showed much higher toxicity than anticipated, and therefore was not recommended for first-line treatment of patients with metastatic renal-cell carcinoma (35).
It shows in Fig. 7 that the NDs and the NRs reveal a much higher degree of toxicity to the HeLa cells than that of the NSs at 24 h at equivalent concentrations of HCPT.
Because of its wide availability paired with comparably high toxicity, (compared to ibuprofen and aspirin) there is a much higher potential for overdose.
