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A series of potent chiral PDE5 inhibitors are described that are based on the sildenafil architecture but exhibit much greater selectivity over PDE6.
In contrast, RACPPPPRSFL (10) showed a slightly lower kcat/ Km (7.3×10 m−1 s−1) for thrombin but much greater selectivity over plasmin (14.3-fold lower kcat/ Km) and factor Xa, which showed no detectable activity towards RACPPPPRSFL.
21, 26 Finally, the structure shows the butyl chain is exposed to solvent on the outer side, supporting the idea that the relatively open active-site arrangement of NagZ accounts for the much greater selectivity demonstrated toward the bacterial hydrolases by the NHAcDNJ -derived inhibitors with more bulky modified N-acyl chains.
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The trade-off obtained did not affect selectivity, with the exception that preference for alfalfa was much greater than selectivity.
We found A66 has a much greater degree of selectivity for p110α than PIK-75.
Hence, enlarging the cyclic prefix improves the data rate only if the power of the remaining distortion due to the frequency selectivity stays much greater than the noise and the distortion caused by the channel time variation.
As to one of the reasons I think that students in other countries seem to be doing better than ours are--even allowing for their greater selectivity of academic students--is as much due to a serious flaw in our culture as other relevant factors such as poverty, the numbers of non-native-speaking immigrants, and undiagnosed or poorly treated learning disabilities.
In contrast the extent of monoalkylation at guanine-N7 as determined by a modified DNA sequencing technique was found to be Busulphan much greater than Hexa-DMS = Octa-DMS, with a sequence selectivity somewhat less than that of other chemotherapeutic alkylating agents such as nitrogen mustards.
As this is a much faster process in insects than mammals, the result is that thiophosphates have a greater selectivity for insects than do their phosphate counterparts.
The selectivity towards p-xylene formation on the dealuminated samples was strongly preferred and much greater than thermodynamic equilibrium data.
The greater selectivity of more elite colleges may indirectly discriminate against low-income students.
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