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Because Mir1-CP acts catalytically, it should have much greater efficacy against larvae than other plant defense proteins such as protease inhibitors and lectins [39].
The mechanism of 2-APB is less clear, but it is recognized as a potent blocker of GJs with a much greater efficacy against Cx40 compared with Cx43.
This is consistent with the data emerging from clinical trials of prophylactic vaccine, which show much greater efficacy in preventing CIN2+ than for low-grade abnormalities.
An analysis of current attempts to achieve this, however, indicates that such a goal may be difficult to achieve, in that pregnancies at-risk for ePE are detected with much greater efficacy than those that develop lPE [115,149].
In this study, pharmacology blockade of MEK1 pathway with U0126 and selumetinib significantly attenuated apoptosis in LMNAR225X/WT as well as LMNAFrameshift/WT iPSC-CMs after electrical stimulation, and selumetinib showed a consistent effect with a much greater efficacy (25 nM vs. 10 μM to rescue apoptosis).
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In addition, combination of a targeted antiangiogenic drug such as bevacizumab with metronomic irinotecan therapy might also be considered in patients not previously treated with this drug since such combinations show much greater antitumour efficacy compared to metronomic chemotherapy alone or the antiangiogenic drug alone (Klement et al, 2000; Kerbel and Kamen, 2004; Pietras and Hanahan, 2005).
Further preclinical steps might be explored such as the combination of a targeted antiangiogenic drug, for example VEGFR-2 tyrosine kinase inhibitors, with metronomic irinotecan therapy, as such combinations show much greater antitumour efficacy compared with metronomic chemotherapy alone or the antiangiogenic drug alone (Klement et al, 2000; Kerbel and Kamen, 2004; Pietras and Hanahan, 2005).
A recent meta-analysis of treatment efficacy for anorectal chlamydia infection found a much greater difference in efficacy: 99.6 % for doxycycline and 82.9 % for azithromycin (efficacy difference of 19.9 %; 95 % CI: 11.4 %, 28.3 %) [ 19].
N- 4-hydroxphenyl) retiN- 4-hydroxphenylmuch greater poteN- 4-hydroxphenylthan ATretinamidebiting cexhibitedh and inducing ceramuch production and cytotoxicity.
Inhibitory efficacy was much greater for compounds with a linker length of n = 2 as compared to n = 3.
In contrast, the effect of self-efficacy was much greater in Bulgaria than in Poland or Germany.
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substantially greater efficacy
significantly greater efficacy
much greater efficiencies
much poorer efficacy
much greater risk
much greater cost
much greater accountability
much greater importance
much greater control
much lower efficacy
much better efficacy
much less efficacy
much greater acceptance
much greater effect
much greater scrutiny
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Justyna Jupowicz-Kozak
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