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We used the Jones-Taylor-Thornton (JTT) amino acid substitution matrix, which is based on the same counting approach as the PAM matrix but uses a much enlarged database [ 33]; it is widely used for phylogenetic analysis [ 16, 17] and is the most suitable choice for vertebrates [ 34].
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In a first step, we reconstructed the phylogeny of a protein family, using an enlarged database containing 1/full length proteins from NCBI NR protein database [ 10] and 2/translation of EST contigs from NCBI dbEST database [ 11].
much enlarged of the second part of the North Am.
The last edition in 1558 was much enlarged and changed.
Paraná's livestock herds have been much enlarged and improved with help from government agencies.
A year goes by, and the "Western" army, much enlarged, acquires howitzers and Gatling guns.
The end of an official letter, much enlarged, frames Sadie Barnette's profile.
Moreover, the act in question very much enlarged the right of appeal, and that was one of its chief objects.
The country's foreign debt was much enlarged, and a precedent had been established of borrowing for political purposes.
Immensely popular in the Middle Ages, it was translated into all western European languages and gradually much enlarged.
This may be much enlarged and adherent to surrounding structures so that its removal may result in serious bleeding.
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