This observation indicated that ER remained functional in tamoxifen-resistant MCF-7 cells, albeit to a much diminished extent.
Despite the reduction of thymic size, there is evidence to suggest that T cell output is still present into old age, albeit much diminished; leading to the assumption that thymocyte development is normal.
In humans large numbers of T cells are produced before birth, but production gradually slows down during adulthood and is much diminished in old age, by which time the thymus has become small and partly atrophied.
RASSF2 suppressed breast tumour cell growth in vitro and in vivo, while the ability of NLS-mutant RASSF2 to suppress growth was much diminished.
Life was much diminished".
Betty was "much diminished" towards the end.
It is still playable, Dr. Blue said, but much diminished.
His influence would have been much diminished in any case.
Frank's confidence in Levin, already much diminished, failed altogether.
After his death the chances of a Tibetan settlement will be much diminished.
Although much diminished by the past 18 years, they do remain independent of Mr Blair.
