Recent reports from a Johns Hopkins University group [ 10] and from The Cancer Genome Atlas Research Network [ 11] have provided a much broader view of the genetic alterations occurring in gliomas.
A much larger sample size with broader genetic background (three pure breeds and one crossbred population) were included in this study in comparison with the other two studies, where only one breed or crossbreed (different from ours) with very small sample size were involved.
With a much broader taxon sampling and multiple genetic markers in our study, the Labrisomini is recovered as monophyletic, but the monophyly of the genus Labrisomus as currently construed is not supported.
Due to their close phylogenetic relationship, Brassica-Arabidopsis comparative genomics promises to identify genetic determinants of a much broader spectrum of variation than might be accessible using Arabidopsis alone [ 12- 14].
Although originally established for the scientific study of mutational mechanisms in human genes, HGMD has since acquired a much broader utility for researchers, physicians, clinicians and genetic counselors as well as for companies specializing in biopharmaceuticals, bioinformatics and personalized genomics.
The effort is part of a much broader debate that spans research and clinical care over which genetic results should be returned an ethical, legal, and practical minefield.
As with B. dendrobatidis, firm conclusions regarding the geographic origins of G. destructans await a much broader global sampling of G. destructans combined with fine-scale population genetic analyses of highly polymorphic markers (Table) (6 ).
The findings also suggest that the genetic heterogeneity that can result in mitochondrial disease appears much broader than previously thought.
This may be due to the genetic heterogeneity within the 'CD44high/CD24low' population [ 14], which suggests a much broader functional variability for this population.
Indeed, using a similar STRUCTURE analysis, Crispo et al. (2006) studied genetic structure among these same guppy populations (in addition to a much broader geographical sampling) and found the most likely number of clusters to be 7.
