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High-speed public local-area networks using Bluetooth and IEEE 802.11 technologies in cafes and airports will compete with the far slower solutions currently available over the much broader cellular and paging systems.
This suggests that activation of the Caspase-2-PIDDosome is potentially relevant to a much broader cellular context than previously described and may serve to protect cells from reparable amounts of DNA damage.
Although this property may be a major contributor to the maintenance of lens clarity, the early changes in the alphaA/BKO lenses indicate a much broader cellular function for alpha-crystallin.
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Furthermore they are likely to function in a context much broader than cellular stress or infection: we find 5′ tRNA halves in unstressed conditions.
Certainly others have indicated that chemokines and their receptors have much broader effects on cellular responses and that our understanding of chemokine function is as yet incomplete [9].
A much broader scope of cellular functions of alpha-crystallin in lens is inferred from in vitro observations.
Similar modulation of the UPR observed in the tunicamycin-treated cells deficient in caspase-7 suggests that the caspase-7 has a much more general role than reprogramming the cellular signaling in T17M RHO photoreceptors and much broader potential applications in UPR regulation.
An alternative hypothesis can be constructed on the premise that the spectrum of mutations affecting this complex disease trait may have a much broader set of targets, needing only to impinge on processes involved in cellular or physiological homeostasis.
We have shown that HPV16 and 18 dampen a cellular immune-related network in HPV-positive KCs, and affect a much broader spectrum of PRR responses than the previously described IRF route.
Mitochondria are critical for cellular adenosine triphosphate (ATP) production; however, recent studies suggest that these organelles fulfill a much broader range of tasks.
The pattern from total cellular small RNA is consistent with primarily miRNA reads, the distribution from exosomes is much broader, encompassing a number of small reads derived from many sources (see Figure 1C,D ).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com