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Furthermore, compound 8n exhibited much better selectivity for HDAC1 over HDAC6 and HDAC8 than SAHA.
Compound 8 bearing an octyl moiety showed much better selectivity for HDAC1 over HDAC7 than largazole (320-fold).
Furthermore, 11b exhibited much better selectivity toward the normal cell lines L929 and Vero than etoposide, 5-Fu and podophyllotoxin.
With this diluted system, the up-flow reactor leads to a higher productivity and a much better selectivity.
HF vapor showed much better selectivity compared to 7 1 BHF solution and it enhanced thickness uniformity between T HfO2 and T SiO2.
Compound 17 bearing a phenyl ring at meta-position was identified to show much better selectivity for HDAC1 over HDAC7 than SAHA.
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The compound II-7 exhibited not only excellent biological activities with IC50 values of nM level in both cell and proteasome models, but also much better subunit selectivity.
Although a set of carbamates of 3-hydroxyevodiamine (10a f) is inactive both at AChE and BChE, carbamates of 5-deoxo-3-hydroxyevodiamine (11a f) exhibit much better potency with selectivity toward BChE.
Only one compound, 2-carboxymethyl-benzenesulfonamide, was more active against hCA V over hCA II (selectivity ratio of 1.39), whereas all other derivatives investigated here were much better hCA II inhibitors (selectivity ratios CA II/CA V in the range of 0.0008 0.73) than hCA V inhibitors.
The results of our studies indicate that Py-EGO has a better durability, much higher selectivity, much better electrochemical stability and high catalytic activity towards the ORR than that of commercial Pt/C electrocatalyst.
Gas and vapor adsorption studies indicated that the new compounds are permanently porous and show much better CO2/O2 and CO2/N2 selectivity and higher vapor adsorption than the tert-butyl analogues.
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