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The study carried out by Gjetting et al. in 2010 established PEG-modified DOTAP/cholesterol lipoplexes as the much better gene delivery system as compared to that of non-PEGylated counterpart [61].
The results of gene transfection showed that the folate-PEG-ligated polymer modified with CRC motifs had much better gene transfection compared to the alanine-ended control and other analogues.
This assumption may also explain why sophisticated methods can rarely find much better gene signatures than simple methods [ 22].
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The previous discussion gave rise to a new, interesting question, namely "Why do peahens prefer to mate with peacocks with elaborate trains?" We let our students discuss this for a couple of minutes, solicited answers, discussed possible explanations, and concluded that peacocks with elaborate trains have much better genes than peacocks with less elaborate trains.
As demonstrated by diagnostic tests for breast cancer, the scores calculated from multiple gene expression correlate with the biology (malignancy) much better than individual gene expression, which includes noise of biological and experimental origin.
It is clear that, even without gap closing, the refined version is a much better source for gene prediction than the original one.
The quantitative correlation between the microarray and qRT-PCR data was much better for downregulated genes (r2 = 0.96, p<0.0001; Supplemental Fig. S3-A) than for upregulated genes (r2 = 0.11, p = 0.59; Supplemental Fig. S3-B).
And combining genomic distance or sequence identity with spatial gene-gene interaction information informs gene-gene function similarity much better than using either one of them alone, suggesting gene-gene interaction information is largely complementary with genomic distance and sequence identity in the context of gene function analysis.
These results further verified that pathway profiling has a much better reproducibility than gene-based methods.
This 31-protein tree is more concordant with my analysis than any other multigene tree I have seen, and is very much better than single-gene (e.g. 16S rRNA) trees in its concordance with organismal characters; the only taxon that would need to be moved across a strongly supported branch to make it concordant with my tree is Aquifex.
Although the accuracy of real-time PCR for the pp65 gene was much better than that for HCMV DNA, pp65 gene expression alone could not be used to distinguish acute HCMV infection from latent infection.
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