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During our screen we found MTs to be stable in the presence of compound B (Fig. 2, panel A and panels C to E), suggesting that taxol prevented MT depolymerization by the compound.
The difference in the fraction of juxtaposed Lys and Cys residues is large enough to allow every one of the eight Tetrahymena MTs to be assigned to the correct group with 99% certainty based on this criterion alone.
So in this case high sequence divergence allows an MTS to be correctly predicted.
DOI: http://dx.doi.org/10.7554/eLife.03197.018 The ability of intrinsically polarized and dynamically unstable MTs to be anchored, stabilized, and regulated allows these filaments to be harnessed by the eukaryotic cell to perform key organizational tasks.
In controls, there was a weak tendency for deviant MTs to be at the fiber periphery, but the overall extent of trajectory deviancy was lower than in TACC3 overexpressing cells.
Similar(55)
Our observations that the MRH2 mutation causes cortical MT to be randomly oriented and fragmented and greatly enhances the CA-rop2-activated disruption of MT organization (Figure 4) suggest that MRH2 is important for stabilizing MT or maintaining MT orientation.
These activities require MT to be present in the nucleus.
When comparing MTs from the ICU populations in both hospitals, most MTs appeared to be ICU-specific (fig. 1/table 4).
How ROCK/myosin II signal to MTs remains to be determined.
In these tubules, the MTs seemed to be present in the tubular lumen as extracellular proteins.
Sites from the Usambara Mts appear to be very heterogeneous in their distribution.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com