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Some MT genes were also upregulated at this time (Figure 6A).
Metallothionein (MT) genes were downregulated in up to 80% of the recurrences.
Coding sequences annotated as orthologues of the human MT genes were extracted from the Ensembl database (www.ensembl.org, release 56: Sep 2009) [19].
Sequences of mt genes were deposited in GenBank (EU805575 - EU805579).
Identical sequences shared between mt genes were identified by Wordmatch (Rice et al. 2000).
In this way, 248 additional Mt genes were predicted to be alternatively spliced.
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This region is the site from which bi-directional transcription of most of the Mt genes is initiated.
In conclusion, pretreatment with mild heat-shock will activate the resistance of nematodes to neurobehavioral toxicity from metal exposure, and MT genes are required for the formation of cross-adaptation response to neurobehavioral toxicity induced by metal exposure in nematodes.
Mt genes are rarely used in green algal systematics.
In addition, several mt genes are duplicated in cephalopods Watasenia scintillans and Todarodes pacificus [ 9].
Zinc-driven transcription of MT genes is controlled by metal-regulatory transcription factor 1 (MTF1) [ 21].
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