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Task blocks were separated by 8000 msec of fixation cross.
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Control 'study' trials consisted of a 3000 msec white fixation cross.
Study trials consisted of a 3000 msec white fixation cross, followed by a study item that appeared for 5000 msecs with a white frame.
In this delayed response task, the subject is required to examine a Stimulus Slide for 3000 msecs and after a delay of 3000 msecs (fixation point), the subject made a determination regarding a final target stimulus (3000 msecs).
Each test trial consisted of a 3000 msec fixation cross.
Two sets of fixation marks were provided.
Each target was immediately followed by a neutral "mask" of 467 466 msec, to total 500 msec of visual stimuli.
T1-weighted images were acquired, with repetition time (msec /echo time (msec) of 500/9 and one signal acquired.
DCE MRI was obtained using 3D Fast FSPGR pulse sequence, with repetition time msec/echo time msec of 5.5/2.6, a matrix of 288 × 288, and nine postcontrast acquisitions.
At the onset of the fixation point (Fig. 2B,a) the animals pulled a lever (Fig. 2B,d), then after 2000 msec an optic flow stimulus was presented concentric to the fixation point (Fig. 2B,b).
Inter-stimuli intervals were set to 1000 msec, duration of target and non-target stimuli were for 500 msec.
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