A 90% CI for ΔQTcF was considered the primary end point; the upper bound at each time point was compared with a 20-msec threshold, which is often used for oncologic compounds where QTc increases >10 and <20 msec have been considered to have a positive benefit:risk ratio 31.
The lower limit of normality for T2∗ in the assessment of myocardial iron load has been considered 20 msec [ 12].
Effective visual masking has been shown with 33 msec targets of happy or fearful faces [4], [6], 30 msec targets of angry faces [5], [21] and 20 msec targets of happy or sad faces [26], [27], or combat/non-combat stimuli [28].
Thus, a 20-msec threshold for meaningful clinical relevance has been commonly used for patients receiving nonadjuvant oncology agents 31.
It has been found that stimuli of around 1 msec need to be separated from one another by in interval of around 30 msec if they are to be perceived as a succession – a result which holds across sensory modalities.
Conclusion and significance: The optimal stimulus paradigm identified in this study (1 msec pulses delivered at 30 to 40 Hz and 2 to 8.5 mA) has been applied to implanted BVFP patients and improved outcome.
However, all patients received ondansetron, a serotonin inhibitor, for antiemetic therapy, which has been associated independently with QTc prolongation by a mean of 15 msec.
Clinically, the QTc has been shown to be an independent predictor for clinical events when >500 msec.
As in other BMI experiments, we use the firing rate as the input over all channels within 100 msec windows, which have been embedded in longer time windows using a gamma memory structure [35].
Indeed, in the ECHO study, QTcF increased over time up to week 48 in both the rilpivirine and efavirenz groups, with no relevant differences between the means (10.9 msec versus 12.0 msec), 3 and only three grade 1 adverse events were reported that might have been related to conduction abnormalities or to rate or rhythm disturbances.
