In the event that CTCAE Grade 3 QTc prolongation was observed (defined as an interval >500 msec or an increase of QTc of >60 msec from baseline with no medically significant symptoms), a confirmatory 12-lead electrocardiogram was required before LY2457546 doses were omitted until the QTc interval returned to <500 msec or below the 60 msec upper boundary.
Respiratory drive as reflected in P0.1 measurement was defined as the pressure change during the first 100 msec from the onset of airflow of a patient's spontaneously initiated breath [ 22].
The categorical QTc analysis showed no patient with a QTcF >450 msec and one patient with an increase of >60 msec from the preantiemetic baseline.
A PCS value for Fridericia's correction of the QT interval (QTcF) was defined as any postbaseline value ≥450 msec for males or ≥470 msec for females with an increase in QTcF of ≥30 msec from baseline.
In the event that CTCAE Grade 4 QTc prolongation was observed (defined as an interval >500 msec or an increase of QTc of >60 msec from baseline with life-threatening signs or symptoms), patients would be considered for withdrawal from the study on the basis of dose-limiting toxicity.
There were no clinically important changes in ECG parameters: no patients had a corrected QT duration of >500 msec during perampanel treatment (whether corrected using Fridericia's formula, QTcF, or Bazett's formula, QTcB), and an increase in the maximum QTc duration of >60 msec from baseline was seen in <1% of patients.
The QT-QS2 increased when compared to supine (-7 +/- 7.6 msec from -22 +/- 7.7 msec [p less than 0.005]), but the QT-QS2 relationship remained normal (QT less than or equal to QS2).
A CR was defined as an NMR within the CS US interval with amplitude ≥0.5 mm and with onset latency >35 msec from CS onset [48].
In our single electrode-based decoding analysis, we combined the power in each electrode optimally linearly across frequency and time (100 900 msec from the stimulus onset, Figure 6C).
For the exemplar electrodes, t-scores from two-tailed t-tests (comparing face>checkerboard) exceeded t>6 (Figure S1B, red), t<−12 and t>14 (Figure S2B, red) around 200 msec from the onset of the static stimuli (uncorrected for multiple comparisons).
