Paired-pulse facilitation in R552H heterozygotes was significantly (p < 0.01) enhanced at short interstimulus intervals (10 75 msec) as compared to that in wild-type littermates, with no detectable differences between genotypes at longer intervals.
Significant impairments were observed in PPF at 20-, 160-, and 320-msec intervals in APP/CCL2 and at 20 msec in APP compared to WT mice (Fig. 2B).
Interwave latencies between wave I and wave III at 70 dB, which are indicative of the afferent auditory nerve conductance were 1.9±0.026 msec in HprtCre/+ Trpml3+/+ animals (n = 6), compared to 1.87±0.026 msec in HprtCre/+ Trpml3 Δ/+ (n = 6), and 1.86±0.019 msec in HprtCre/+ Trpml3 Δ/Δ littermates (n = 6).
Additionally, parietal NAWM and cerebellar NAWM exhibited a trend toward higher T2 values in patients compared to HC (parietal NAWM T2: 83.5 ± 2.44 msec in patients compared to 81.8 ± 2.62 msec in HC; d = 0.7, P = 0.05; and cerebellar WM T2: 85.90 ± 1.69 msec in patients compared to 85.48 ± 1.47 msec in HC; d = 1.62, P = 0.07).
In addition, SERCA2a transduction significantly improved the time course of relaxation (tau) compared to DM hearts (19.6±2.4 vs 25.0±5.8 msec, P<0.05) (Fig. 1E).
Therefore, a significant choice probability >0.5 indicated that the EEG signal at that time lag (within a 100 msec window) was significantly more positive for hit trials compared to miss trials.
This is an improvement reducing the average scanning delay per vehicle by approximately 60% regardless of the scanning mode compared to the mean scanning time of 750 msec in [5] for active scanning and 1200 ms for passive scanning.
At 500 msec SOA, implausible words related to predictable words elicited reduced N400 amplitudes compared to unrelated words (PINES vs TULIPS), replicating past studies.
Sprague Dawley (SD) rats are more sensitive to PPI-disruptive effects of apomorphine (APO) at long interstimulus intervals (ISIs) (60 120 msec) and less sensitive to PPI-enhancing effects of APO at short ISIs (10 30 msec) compared with Long Evans (LE) rats.
Number of GFP molecules per pixel was computed (∼7700) and compared to the mean pixel fluorescence (∼3000 fluorescence A.U. per 1000 msec exposure), and summed up to ∼0.4 fluorescence counts per molecule.
