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The MRS scan was initiated if the line width reported by the prescan process was less than 6 Hz.
Of the remaining 65 men from the lowest and 66 from the highest quintile, 15 (23.1%) and 16 (24.2%), respectively, agreed to undergo an MRS scan.
The MRS scans were performed an average of 6.0 (SD = 1.2) years after the KXRF measurements; therefore, we report on additional analyses after adjusting each subject's patella bone lead levels for the years between the bone measurement and the MRS scan based on a first-order exponential decay function with a half-life of 8 years as determined previously among NAS participants (Kim et al. 1997).
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Since the DTI scans are much less time-consuming than MRS scans, we acquired whole brain DTI and extracted matching voxels for correlation analysis with the MRS voxels.
The MRS scans in the intra-individual study design showed a significant increase in myo-inositol in the analyzed regions.
The pigments and dyes were analysed by micro-Raman spectroscopy (MRS), scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM EDS), and high-performance liquid chromatography with diode-array detection (HPLC DAD).
For the post-mortem measures including IBA-1, SYN, MAP2, GFAP, neuronal counts and last MRS scans before sacrifice, ANOVA was performed among the cohorts and if found to be significant, Least Square Means Student's t-tests were used to isolate which cohort was significantly different.
MRS scanning was performed on both control and patient groups before SSRIs treatment.
MRS scans were conducted intermittently during this period, prior to feeding.
All MRI examinations were carried out on a 3T whole body scanner with all P MRS scans conducted using a dual-tuned H/P head coil.
Three patients (two male and one female from the BA group) presented unreliable MRS scans at either PRE or POST-12 and were excluded from all analyses involving muscle carnosine determination, and all correlations.
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