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Decreasing extent of marrow invasion, reduction of tumour volume and a decrease in the amount of associated oedema are favourable conventional MRI indicators (Fig. 25).
As we were interested in early MRI indicators of response, we first confirmed the responsiveness to 4 days of selumetinib treatment in the BRAFV600D mutant WM266.4 human melanoma xenograft model.
The quantitative concentration of Gd taken up by the cells provided an MRI-relevant indicator for the uptake of the paramagnetic liposomes.
Examples include modeling pharmacokinetic/dynamic (PK/PD), radiological (CT, PET, MRI) and multiple indicator dilution (MID) data.
From the preliminary results of the prospective data, we once again recognise the importance of change in lesion density (with computed tomography) and/or signal intensity (with magnetic resonance imaging, MRI) as an indicator of response to therapy.
A purely lytic component and contrast medium uptake on MRI are excellent indicators of the high-grade part of the tumour (Fig. 6a), guiding the biopsy.
Current methods for imaging in breast cancer are described, and a review of recent studies that compared dynamic contrast-enhanced MRI with histopathological indicators of tumour vascular status is provided.
The apparent diffusion coefficient on diffusion-weighted MRI is also an indicator [ 21, 22].
To determine whether CE MRI is an accurate indicator of tumour response to neoadjuvant chemotherapy in comparison to the histopathology gold standard.
The aims of our study were: To determine whether CE MRI is an accurate indicator of tumour response to neoadjuvant chemotherapy in comparison to the histopathology gold standard.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com