The Z 1/2 and Z mp parameters are calculated from the probability distribution function (PDF) of heights f(Z) that satisfy the equations ( {int}_{-infty}^{Z_{1/2}}f(Z dZ={int}_{Z_{1/2}}^{infty }f(Z dZ=1/2 ) and ( frac{d}{dZ}{int}_{-infty}^{infty }f(Z dZ=0 ).
These included the parameters representing apoptosis (γ1, γ2, γ3, and γ MP ), the parameter representing TGN incorporation (f), and lastly, the parameters representing the viable cell dynamics after TGN incorporation (α SI, β I, and α MI ).
The authors hypothesized that the lack of association between mp-MRI parameters and aggressiveness may partly be due to the reference standard used or the small sample size.
The score test was used to select the mp-MRI parameters most likely to contribute significantly (p < 0.05) for inclusion in each model [ 23].
Although the Gleason score has been shown to correlate with quantitative mp-MRI parameters in the untreated prostate [ 101– 103], they did not find a significant association between the Gleason score and these parameters in irradiated prostates.
Assuming the counts to have a Poisson distribution with parameter Mp, we can approximate them with a normal distribution with mean Mp and variance Mp for large sample sizes.
All these proposed criteria are given as function of the mixity parameter Mp and the hardening exponent n of the material.
Based on the generalized HRR [ASTM STP 560 (1974) 187] solution and on the knowledge of the mixity parameter Mp, the RKR based criterion is transformed into a J Mp based criterion.
Modeltest 3.6 [ 66] was used to estimate parameters of DNA substitution model for the six-parameter MP, ML and BI analyses.
The response to P was best fitted by a sum of two exponentials (equation E-4) and parameters mP, MP, c and d: RP(D) = MP × ecD + (MP-mP) × edD (E-4) Values of these parameters and the fitting quality are given in Table 2.
