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Moving motor vehicles injure and kill hundreds of thousands of pedestrians each year.
In the five-year period from 2009 to 2013, over 20,000 pedestrians were killed in the United States by moving motor vehicles (National Highway Traffic Safety Administration, 2015).
Adults are increasingly just as guilty of checking Facebook messages in a moving motor vehicle, so that equates to a lot more distracted drivers on the road during the summer months.
We show below that these runs were actually caused by stepwise moving motor heads.
This may reflect the higher probability of a fast moving motor from engaging hTpx2 molecules that are bound on the microtubule lattice.
(F ) Distribution of the initial size of processively moving complexes based on the brightness of a single fluorophore from E. (G ) Histogram of moving motor complexes containing the indicated number of Cik1-Kar3 heterodimers.
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(C ) Rab6A decreases the percentage of moving motors (p < 0.0001, bars = SE).
Moving motors were defined as those moving >0.12 µm/s for a distance of >0.2 µm that were tracked for >0.9 s.
Quantification of TMR brightness of moving motors allowed us to compare the motile properties of Cik1 Kar3 heterodimers vs larger teams that consisted of two or more heterodimers.
Fourth, the very low number of moving motors is troublesome; suggested to be due to autoinhbition but not really followed up.
The percentage of moving motors also decreased 60% in the presence of Rab6A (from 2.13% to 0.86%; p < 0.0001; Figure 5 figure supplement 1C).
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