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Moving From Evidence to Action.
Moving From Evidence to Action -- Pt. 2. Beyond the Basics: Using and Teaching the Principles of Evidence-Based Medicine -- 2A.
Evidence-based medicine recommends that one search for the highest level of evidence available, integrate this evidence with clinical experience and judgement, and acknowledge the value judgments implicit in moving from evidence to action.
Relating the narrative to the framework of institutions, interests and ideas, it demonstrates how 'contextual factors' aligned favourably to shape the process of moving from evidence to policy.
Differences in recommendations may reflect not only differences in material sourced, differences in interpreting and grading the evidence but also different influences in moving from evidence to recommendations.
Despite the progress in defining criteria for trustworthy guideline development, gaps in research around guideline group composition and processes, determining and implementing criteria for moving from evidence to recommendations and developing recommendations about diagnostic tests and strategies are apparent.
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The challenge is to move from evidence of efficacy (temperature reduction) to evidence of effectiveness and improved patient outcomes.
Decisionmaking in healthcare is a complex process taking place along a continuum that moves from evidence generation to deliberation on each particular intervention and communication of the resultant decision.
The SoF will be used to move from evidence to recommendations and to ensure that the ONTOP group uniformly considered the quality of the evidence, the certainty about the balance of benefits versus harms, the similarity in patients' values and preferences and the costs of an intervention compared with the available alternatives.
The application of COMER in decision-making may allow decision-makers to move from evidence-based medicine to economic evaluation based on evidence, understanding evidence within a comprehensive framework where both clinical and economic evidence are compatible.
Third, the evidence systematically retrieved from the medical literature will be evaluated using the GRADE method, which provides a systematic and transparent framework for prioritising clinical questions and determining the outcomes of interest, summarising the evidence that addresses a question, and moving from the evidence to a treatment recommendation or decision.
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