Exact(1)
These dyes are fluorescent molecules used to monitor the movement of synaptic vesicles.
Similar(59)
The nerve terminal contains more than 400 different proteins, which together form the exquisite molecular machinery that regulates the fusion, recycling, and movements of synaptic vesicles between the reservoir pool, active zone and cell membrane.
This spectacular image – which took the best part of a year to create – shows the fine structure of a nerve terminal at high resolution, revealing, for the very first time, an intricate network of fine filaments that controls the movements of synaptic vesicles.
However, the movement of single synaptic messengers on route to the nucleus has never been directly tracked, and therefore this point remains to be clarified.
Transport kinesins play amongst others an essential role in the cytosolic movement and localization of synaptic vesicles in neurons and in physiological axonal transport processes [ 11].
Thus, the sequestration of Zn2+ in oligomeric Aβ-Zn complexes may lead to a reduction in zinc turnover at the synapse, limiting the trans-synaptic movement of zinc to modulate post-synaptic targets, and resulting in impaired cognition.
These findings are consistent with previous studies showing that rollover movement defects occur independently of synaptic transmission defects (Bodily et al., 2001), and suggest that defective NMJ architecture impairs the muscle control that is required to coordinate the sequence of motor outputs to optimally produce a bilateral coordinated movement (twist-and-roll behavior).
19, 20 The transporters are more likely involved in compensating the movement of Cl− during fast synaptic transmission in order to reset ECl and water flux.
The proportion of PAP+ASI+ spines in W was significantly higher than S (68.23 ± 6.26%% vs 51.09 ± 7.88 %, P = 0.023; Additional file 10: Figure S2), and comparable to SD (MW, P = 0.59) and CSR (MW, P = 0.79), indicating that the movement of PAPs toward the synaptic cleft is not caused by the stress of sleep deprivation.
To allow the trans-synaptic movement of rabies, an additional retrograde virus encoding the rabies glycoprotein can be co-injected into the muscle, which will then trans-complement Rabies-ΔG in the motor neurons resulting in monosynaptic spread (Stepien et al., 2010).
Spontaneous electrical activity underlies the generation of rhythmic motor movements (or limb movements) in the developing chicken embryo following the establishment of synaptic connections between nerve terminals and muscle fibers at E6 (corresponding to stage 28 29) [9].
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