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These "giant cells" have been extremely useful in studies of cytoplasmic streaming (the movement of cell contents) because it is possible to see this happening even under relatively low magnification.
The novel aspect of these systems include automation of imaging by robotic movement of cell culture flasks, which enables selection of a large number of regions of interest for data collection.
Studies using immunofluorescence microscopy and pharmacological approaches have shown that microtubules and/or actin filaments are involved in many of these events through the generation of intracellular movement of cell components or entire protoplasmic contents and the spatial control of cell activities in specific areas of the giant cells.
The concentration of actin at the cell wall indicates either continued growth of the cell or movement of cell wall components for cell wall repair [36].
This increased response of microglia comprised a rapid movement of cell somata towards the lesion site (in some cases even within a few minutes after the lesion) combined with early phagocytic activity (Fig. 2A; Videos S3 and S4).
When cells did eventually move their somata forward, the rear membrane often required a longer period of time to resolve; kymographs revealed that the movement of cell rears formed a sloped line rather than a discrete jump (Figure 3C).
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Poo combined physics and biology early in his career to study the movement of cell-membrane proteins.
Filamentous extracellular appendages that are responsible for the active movement of cells in a liquid environment.
Movement of cells out of primary tumors is the chief cause of mortality in cancer.
And he says it may also help inhibit the movement of cells essential to the growth of cancer.
Movement of cells to distant organs, and their resultant destruction, constitutes a primary cause of cancer-associated morbidity and mortality3.
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