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Studying cell movement in melanoma is particularly important because it is the metastatic tumors that kill patients.
What we know about the role of Dock10 comes from a single study using gene silencing, showing Dock10 as a factor that sustains the rounded morphology and amoeboid-type movement in melanoma cells (Gadea et al., 2008).
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Pinner and Sahai [41] showed that a fine balance between PDK1 and Rnd3 expression is required for the amoeboid movement of melanoma cells, because the two proteins have opposing roles in controlling ROCK-I activity.
Therefore, we here used melanoma spheroids embedded in a basement-membrane-like extract (matrigel) to mimic the invasive movement of melanoma cells through the basement membrane.
And she has taken an active role in melanoma awareness.
The increase in melanoma is real, she said, and "the only logical explanation is environmental exposure".
Computer vision may aid in melanoma detection.
An interesting paradigm has been suggested in melanoma cell lines.
We engineered an oncolytic measles virus entering melanoma cells through the high molecular weight melanoma associated antigen (HMWMAA) and proved highly specific infection and spread in melanoma cells.
The new findings may also partly explain the recent rise in melanoma among young women, which has increased more rapidly than melanoma in men, the researchers said.
Nucleoli are prominent in melanoma cells.
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