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First, co-removal of dGALK fully corrected the behavioral movement defects of dGALT nulls (Fig. 5C).
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Motility defects of pronephric cilia vary in mutant strains from complete paralysis to an increased frequency of movement, and are associated with left right asymmetry defects.
Some American and Afghan officials believe that the Taliban is vulnerable to being split, with potentially large chunks of the movement defecting to the Afghan government.
These findings are consistent with previous studies showing that rollover movement defects occur independently of synaptic transmission defects (Bodily et al., 2001), and suggest that defective NMJ architecture impairs the muscle control that is required to coordinate the sequence of motor outputs to optimally produce a bilateral coordinated movement (twist-and-roll behavior).
Finally, we observed movement defects (inching) following knockdown of a homolog of B9 domain-containing protein 2 (Smed-b9d2).
The mechanistic basis of CG movement defects remains unknown after 50 years of study (Bosch, 2006).
Expression of BRAF CFC and MEK CFC mutant alleles in zebrafish embryos causes cell movement defects during early development, indicative of activated FGF-MAPK signalling in gastrulation cell movements (convergence-extension) (Krens et al., 2008).
Along these same lines, the movement defects we observed following knockdown of Smed-b9d2 in planarians are likely directly linked to a conserved function in the production of the ventral cilia the animals use for gliding.
By contrast, overexpression of either BRAFQ257R or BRAFG596V promotes cell movement defects during gastrulation, consistent with enhanced activation of the MAPK signalling pathway in vivo (Fig. 3A).
Loss of function of these components leads to movement defects and aberrant postsynaptic currents, without affecting presynaptic function.
unc-18 sy671) unc-18 sy671omotor defects, whase mild other alocomotor unc-18 have severe movement defects.
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