It is still unclear why the global synaptic deficit in Bdr mice would influence certain behavioural parameters and not others, although we hypothesise that events causing the continual, rapid firing of neurons would result in depletion of the reserve pool of vesicles, ultimately preventing normal synaptic function.
The second aim of our study was thus to assess whether the VCAM-1 expression pattern in retinal vessels was different in dyslipidemic compared to wild type (wt) mouse, and how diabetes would influence such an expression.
The primary objective was to determine if HJ8.5 administered at a dose of 50 mg kg−1 week−1 by intraperitoneal (IP) injection to 6-month-old P301S mice for 3 months would influence phospho-tau (p-tau) accumulation, tau insolubility, and neurodegeneration.
Since our previous studies demonstrated that loss of CB1 defers the normal implantation window in mice, we surmised that CB1 deficiency would influence parturition events.
In order to test whether the B cell depletion and alteration of the splenic architecture, induced by the treatment, would influence humoral immune responses, mice were immunized with NIP-ficoll or NIP-ovalbumin 10 days after treatment with 9B9 mAb.
We first determined whether the loss of Clecsf8 would influence the survival of mice during infection with live mycobacteria.
To investigate whether higher doses of MB would influence TauRDΔK pathology, the mice were treated with an excessive dose of MB (40 mg/kg/day MB) for 3mo.
We predicted that variations in ambient temperature during the early postnatal period would influence body composition in developing mice and would affect susceptibility to DIO in adulthood.
Tyrp1 b Gpnmb R150X mice exhibit a pigment-dispersing iris disease that is clinically, and mechanistically, similar to that in D2 mice, we next tested whether the B6 genetic background would influence the impact of this insult on IOP.
Using a 2×2 factorial design, we investigated whether a heterozygous deletion of GR would influence maternal care behavior in C57BL/6 and Balb/c mice, two inbred strains known to display qualitative differences in this behavior.
