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Jaggi picked up on the symbolism of the final image: "the escape of a small brown laboratory mouse, which may be genetically programmed to turn albino-white, but which gladly seizes its freedom and runs with it".
Its final image is the escape of a small brown laboratory mouse, which may be genetically programmed to turn albino-white, but which gladly seizes its freedom and runs with it.
Furthermore, we exploited these undifferentiated photoprotein mES cells to produce a transgenic mouse, which may be useful for ex vivo imaging studies and as a source of differentiated primary cells expressing a Ca2+ reporter gene.
However, no detectable YFP expression was found in the retina of Opn4Cre/+ mouse, which may be due to weak transcriptional activity from the native melanopsin promoter and/or low expression of the second transcript downstream of an internal ribosomal entry site (IRES) cassette.
This result suggests that GM genes are evolutionarily more stable in NMR than in mouse, which may be required for longevity and/or resistance to cancer in NMR.
Nevertheless, the proliferation rate in the eye of the Iberian mole is very low in relation to the mouse, which may be the cause of its reduced size.
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In the short run, this leads to smarter mice, which may seem a dubious achievement.
There were also signs of DNA damage in spinal cord motor neurons of AR100 mice, which may result from downregulation of DNA repair genes and/or mitochondrial dysfunction.
Skin picking is also common among laboratory mice, which may develop potentially fatal ulcerative dermatitis, skin lesions, caused by excessive grooming.
The red pulp compartment showed a significantly (P < 0.05) increased average number of megakaryocytes compared with uninfected mice, which may be associated with hematopoietic reconstitution.
Furthermore we have found evidence for improved neurotrophin function in these trisomic mice, which may contribute to the protection of BFCN neurons in these mice, and subsequently their improved cognitive functioning.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com