In conclusion, the present study has identified hypothalamic gene signatures of exaggerated circadian BP changes in hypertension in the Schlager BPH/2J mouse, which displays a morning BP surge similar to that seen in human essential hypertension.
Compared to the diabetic NOD mouse, which displays characteristics of early human diabetic nephropathy, the diabetic OVE26 transgenic mouse, displays characteristics significantly closer to advanced human diabetic nephropathy [ 24], which include notably a dramatic increase of urinary albumin excretion.
The most studied medulloblastoma mouse model is the Ptch1+/− mouse, which displays abnormally high GCP proliferation leading to medulloblastoma formation between 3 and 6 months of age (Goodrich et al., 1997).
Furthermore, we have shown that exogenous Reelin can recover defects in the heterozygous reeler mouse, which displays significantly reduced levels of the Reelin protein compared with wild-type mice and exhibits deficits in synaptic function and learning and memory (Rogers et al., 2013).
Cardiac stress testing demonstrated significant heart disease in α-DB null (adbn−/−) mice, which displayed mortality and lesion sizes that were equivalent to those seen in dystrophin-deficient mdx mice.
Clock-Δ19 mice, which displayed an increased propensity to enter the open section of the elevated maze, showed profound deficits in these anxiety-related circuit processes.
Interestingly, bone density was considerably decreased in male TH mice, which displayed hyperglycemia.
Egr-1−/− mice, which displayed basal airspace enlargement, resisted cigarette-smoke induced autophagy, apoptosis, and emphysema.
This finding resonates strongly with the initial experiments on Rest−/− mice, which displayed embryonic lethality around E11, but importantly, showed no widespread precocious expression of Rest target genes.
These results indicate that Egr-1−/− mice, which displayed basal airspace enlargement, resisted cigarette-smoke induced autophagy and apoptosis, as well as further changes in airspace enlargement as assessed by MLI.
