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These cells (1×106 HSCs per mouse) were then injected directly into HLA-A*0201+ HLA-A*0201+c implants in sub-lethuman irradiathymicimplantsce.

Reconstituted recipient mice bearing hematopoietic cells with the genetic background of the donor mouse and non-hematopoietic cells with the genetic background of the host mouse were then injected with BLM to assess disease development.

Photons emitted from the mouse were then detected in complete darkness, collected and integrated for a period of 2 min. A pseudo color image represents light intensity (blue as the least intense and red as the most intense).

Following duplications, mainly in mouse, were then lineage-specific [ 46].

Orthologous gene pairs containing conserved 3-TFBS combination between human and mouse were then selected.

The targeted mouse were then mated with B6.C-Tg (CMV-cre)1Cgn mouse to delete exon 2 and exon 3 of gene Ildr1.

The mouse was then placed back in its cage.

Each mouse was then immediately returned to its home cage from the treadmill.

The mouse was then removed from the platform and returned to its home cage.

The mouse was then awoken with an injection of 2.5 mg/kg Antisedan.

The new average for each mouse was then calculated.