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Other unique features of beta-cells transcriptome (with over 1000 lincRNAs expressed in mouse) were obtained from another study [8].
Spleens were removed aseptically and single-cell splenocyte suspensions from each mouse were obtained by passing the spleens through sterile 40 µm cell strainers (Fisher Scientific; Pittsburgh, PA).
Full-length cDNA datasets for human and mouse were obtained from the H-InvDB (www.h-invitational.jp/) and Fantom3 (http://fantom3.gsc.riken.jp/) databases respectively.
Cryopreserved embryos (011832-UCD-Embryos) of PK2-EGFP transgenic mouse were obtained from the Mutant Mouse Regional Resource Centers MMRRC, University of Californiaatat Davis) and recovered by the Transgenic Mouse Facility at University of California, Irvine.
Disease gene sets for mouse were obtained from the Rat Genome Database (RGD) Disease Portal [ 54].
Whole-mount preparations of the organ of Corti of mouse were obtained as follows.
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Amyloid beta (mouse) was obtained from Novacastra Laboratories Ltd ,Newcastle, UK.
Human HLA (MHC2) (mouse) was obtained from Dakocytomation, Denmark A/S.
Tau (mouse) was obtained from Novacastra Laboratories Ltd ,Newcastle, UK.
DNA from each mouse was obtained from tail biopsies.
OT-II transgenic mice were obtained from the Jackson Laboratory.
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