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Nude mouse weight, tumor weight and tumor volume data indicated that the GC GO DOX tumor inhibition effect was better than that of the control group and the blank group.
At the time of sacrifice, mouse weight, tumor weight, number of nodules, and distribution of tumors were recorded.
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However, there is no overall correlation between tumor latency time and mouse weight at tumor detection date (Additional file 1: Figure S5), indicating that chronic treatment of X10 and IGF1 affects tumor latency directly by mitogenic signaling rather than indirectly by obesity.
Mouse weight and tumor sizes (diameters) were periodically measured and lesion diameters were converted to tumor volume using the following formula: V = length × width × height × 0.52.
Mouse weight and tumor size were measured twice per week.
VLP H1 and VLP H2 inhibited tumor growth (A), reduced mouse weight (B), and tumor volumes (C) but did not decrease mouse body weights (D).
This polymeric nanoparticle substantially enhanced antitumor efficacy compared to the free DOX, exhibiting much higher effects on inhibiting proliferation and inducing apoptosis on the 4T1 murine breast cancer model confirmed by the evidences from mice weight shifts, tumor growth curves, tumor growth inhibition (TGI), immunohistochemical analysis and histological assessment.
Mouse weights and tumor volumes were measured every two days in the first two weeks of treatment and then once a week.
Mouse weights and tumor volumes (1/2 length × width) were measured three times per week.
After 14 days, mice weight and tumor volume were recorded.
The mean tumor volume and mouse weight were used to construct the curves of tumor growth versus mouse growth to evaluate therapeutic efficiency and toxicity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com