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Mouse weight increased faster in HFD groups than in the ND ones.
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In control mice, muscle weight increased progressively throughout life.
Thirty days after initiating treatment, sham treated mice body weight increased by14.6 ± 2.8% while on HFD (OB/HFD/Sham).
No mice died during the treatment and, in fact, mouse body weights increased comparably to vehicle-treated mice (Fig. S7A).
Gli1 homozygous null mice have reduced body weight, increased postnatal lethality, and defects in T-cell development, while heterozygotes are of normal weight but have reduced bone mass, reflecting the importance of normal levels of GLI1 for bone homeostasis and immune function (Kitaura et al., 2014, Drakopoulou et al., 2010).
Adult control prostate weights in our reproductive toxicity studies with E2 (Tyl et al. 2008a, 2008b) and BPA (Tyl et al. 2008c) (Table 1) are well within the weight range of other published studies (Table 2), and, as expected, our mouse prostate weights increased with increasing age.
Comparison of mice weights revealed that while weight increased dramatically in both saline and unconjugated Ab treatment groups as a result of rapid tumour growth, immunoconjugate treated mice underwent weight loss during the first 2 weeks following total eradication of the tumours.
In contrast, Nlrp3 KO did not lose body or liver weight, while spleen weight increased in these mice during sepsis (Fig. 3b; Additional file 4A, B).
In obese, insulin-resistant mice, weight loss increased PPAR-γ expression [17], and both starvation and endurance training activated PPAR-δ in healthy animals [18, 19].
During the beginning 2 weeks after Salmonella infection, the mice body weights increasing rates from the three Salmonella infected groups all slowed down, until week 2 or 3, the average weight of all the three Salmonella treated groups were significantly lower that the control group at the.05 significance level.
On the other hand, Y1R knockout mice (Kushi et al, 1998) have higher body weights and more white adipose tissue, while both Y2R and Y5R knockout mice also have higher body weights, increased food intake and greater adipose deposition though in the Y5R knockout mice this only occurs later in life (Marsh et al, 1998; Naveilhan et al, 1999).
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