However, stay time on 35°C floor in wild-type mice was longer than that in TRPM8-deficient mice.
The overall median survival of the mice was longer (by ∼13 days) in doxycycline-treated mice than placebo-treated mice (Fig. 6E).
The t1/2 in Abcc2−/− mice was longer than in the parental (2.46 vs. 1.92 h), and consequently a similar AUC0 ∞ for parental and Abcc2−/− was observed (168 vs. 145 μg/L h).
On the other hand, the time course of the spontaneous disease in this model and also in Aire knockout B10.RIII mice was longer, with an onset of about 6 weeks instead of the usual 2 weeks in the original model [47].
Additionally, the DSS-treated mice exhibited a significant shortening of the colon, but the large intestines of the rTl-GAL pre-treated mice were longer than those of the control group (P < 0.05).
Despite the marked increase of body weights in Leptin145E/145E mice, body lengths of Leptin145E/145E mice were longer than Leptin+/+ mice by about 7% (Figure 2C).
Second, telomeres in livers from Slx4−/− mice were longer than in Slx4+/− mice or wild-type mice.
Although mice have provided valuable insights into telomere biology, a fundamental difference is that telomere length in mice is longer than in humans, which could explain why mouse models do not recapitulate all the symptoms of DC.
Generally the IP of UK-1 and UK-2 following primary isolation in wild-type mice were longer compared with those obtained from the same mouse lines challenged with ovine or bovine BSE in agreement with previously published data (14).
Although the immunizations did not provide complete protection against acute challenge with T. gondii, the survival time of mice is longer and the survival rate was significantly increased than control groups.
