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The titanium dorsal skin fold chamber (APJ Trading Co. Inc, Ventura, Ca) surgically mounted onto each mouse was described previously [18].
The Polg D257A mouse was described previously.
Generation of the TrkA f/f (TrkA F592A ) mouse was described previously (Chen et al., 2005).
The generation of the Dyrk1a+/− mouse and the mBACtg Dyrk1a mouse was described previously.
Recently, an Integrin-β6 (Itgb6) null mouse was described with a hypomaturation AI phenotype (18), but to date no human mutations have been identified in this gene as a cause of AI.
Additional description about the Wnt1Cre TrkA f/f mouse has been added to the Materials and methods section: "Generation of the TrkAf/f (TrkAF592A) mouse was described previously (Chen et al., 2005).
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The generation of R26floxneoΔ256Foxo1 mice was described previously [6].
The generation of the Crb1−/− mice was described previously [20].
Generation of Psen cDKO (fPS1/fPS1 PS2−/− Cre) mice was described previously [10].
The generation of the NPY −/− mice was described previously [21].
Generation of Mst1−/− and Mst2−/− mice was described in a separate publication [32].
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