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Yet Mickey Mouse was created in a time of turmoil.
The compact, wireless mouse was created with the mobile professional in mind, and is designed to work in the air or on a flat surface like a desktop.
Since the organ-to-body weight ratio is necessary to extrapolate to humans and to create consistent time-activity curves from the obtained average organ activity per volume or gram of tissue, a 'standard mouse' was created using six C57BL-6 mice.
The Tau knockout mouse was created by H. Dawson and colleagues by homologous recombination replacing exon 1 with a neomycin expression cassette [ 25].
To understand the functions of saposin C in vivo, a saposin C-deficient mouse was created in the presence of near-normal amounts of saposins A, B and D that are derived from prosaposin.
This mouse was created by introducing a mutation in a splice enhancer site in the murine Smn gene, resulting in production of 10-15 % of normal Smn levels [ 20].
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KO mice were created upon a Black Swiss background.
Additionally, it should be noted that the KO mice were created on a Black Swiss strain background.
The mice were created "completely by chance," says biologist Suzie Chen of Rutgers University in Piscataway, New Jersey.
Transgenic mice were created with cardiac-specific overexpression of the beta 2-adrenergic receptor.
Initially, heteroplasmic mice were created to explore disease pathogenesis and mitochondrial dynamics in an in vivo system.
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