We adjust expected coverage higher and shift expected MAF values based on the estimated amount of mouse contamination in the region (The mouse is assumed to come from an inbred line, so it will be diploid and homozygous for most mouse-specific SNVs).
Body temperatures of all mice were assumed to be 37 °C and to remain constant during the ventilation protocol14.
The band (arrow) corresponding to the positive control in the Tg and WT mice is assumed to represent OCT2 protein abundance (e) (values are relative to total protein and represent mean ± SEM, n = 7) (*P = 0.026).
Thus, for a given experiment, the mice were assumed to be in similar phases of the estrus cycle.
(19, 20) With the pharmacokinetic parameters of lapatinib and S-222611 in nude mice (Table S4), the clinically relevant doses in mice are assumed to be approximately 50 and 50 100 mg/kg for lapatinib and S-222611, respectively.
First, the single-dose PK parameters determined in the NMRI mice were assumed to be similar to the multiple-dose PK parameters and were correlated with the efficacy data for KAE609.
Our results emphasize the importance of COMP in cartilage stability, and the mechanism underlying the exacerbation of CIA in COMP-deficient mice is assumed to be found in COMP-dependent changes in the cartilage erosion/repair process.
Uncertainty in determination of KD and koff from mouse data was assumed negligible in comparison to uncertainty in translation.
Based on this 11-month tumor bioassay of Wy-14,643 (Peters et al. 1997) and the short-term DEHP study (Ward et al. 1998) in PPAR-α null mice, it was assumed that "a long-term study of DEHPPAR-α nullR-α–null mice would provite the same results" (Klaunig et al. 2003).
Because the megakaryocyte number in bone marrow in these mice was remained higher than in WT mice, PLT production was assumed not to have decreased.
