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177Lu-DOTANOC (5 MBq, 2.5 nmol per mouse) was administered intravenously (i.v).v
Also, it showed inhibition against H3N2 subtype of influenza A virus, and exhibited remarkable therapeutic effect on mouse pulmonic induced by influenza virus when the mouse was administered with the essential oil (100 mg/kg) [41].
Each mouse was administered diazepam (3 mg/kg, suspended in 0.5% carboxymethylcellulose solution) or vehicle i.p.
Each mouse was administered imipramine hydrochloride (20 mg/kg, dissolved in saline) or vehicle i.p. 30 min before the trial.
Each mouse was administered 200 cfu i.p. and the dose was enumerated by plating on LB agar media.
At the end of this period, each mouse was administered the unconditional stimulus consisting of lithium chloride [20 ul/gm volume, 0.15 M lithium chloride (LiCl) injected IP], and placed back into the cage.
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For VSV strain Indiana, 10 PFU per mouse were administered intranasally.
One group of mice was administered dex (1 mg/kg i.p).
Another group of mice was administered normal saline which served as negative control.
Another group of mice was administered control vehicle (10 ml/kg) orally as the negative control.
Another group of mice was administered saline (10 ml/kg, p.o). served as negative control.
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