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BMPER is important in long-range relocalization of chordin during mouse vertebral development [ 27].
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These findings suggest that LOXL3 is crucial for palatal and vertebral development in mice.
The six stages of vertebral development include: (1) gastrulation and formation of the somitic mesoderm and notochord, (2) condensation of the somitic mesoderm into somites, (3) formation of dermomyotomes and sclerotomes, (4) formation of membranous somites and re-segmentation with definitive vertebral formation, (5) vertebral chondrification and (6) vertebral ossification.
Congenital scoliosis is usually caused by abnormal vertebral development in utero.
Besides its role in anterior neural patterning, Dkk1 is involved in limb formation [10], [11], vertebral development [12], bone formation [13], [14] and bilateral eye induction [8].
Congenital scoliosis results from defects in the embryological vertebral development.
All three QTL contain candidate genes which are known to be associated with vertebral development.
Mouse vertebral columns were dissected whole from freshly sacrificed mice and post-fixed in 4% paraformaldehyde overnight, 4°C.
This has made it possible to characterize in detail both notochord segmentation and the subsequent mineralisation that nucleates vertebral development.
By 5 days after fertilization, TCDD-exposed fish exhibited gross dysmorphogenesis in cranio-facial and vertebral development.
In this work, 20 skeletal genes were used to study the effect of long term hyperthermic exposure on vertebral development and growth in Atlantic salmon.
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