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One function of the mouse version of Sir2, called SIRT1, is to regulate how genes are expressed in various tissues.
The tissues kept in the culture medium are from the striatum of the brains of mice that carry the Huntington gene homolog (the mouse version of the gene).
One of the more famous examples is how the introduction of an extra gene in mousepox – the mouse version of smallpox – made it far more lethal and able to infect vaccinated individuals.
Visuo-spatial learning and memory were assessed in male and female mice of 13 inbred strains on a small diameter mouse version of the Barnes maze surrounded by a wall and intra-maze visual cues.
The next step will be to test the idea in mice — something of a challenge, since there is not a particularly good mouse version of celiac disease on which to test the TG2 switch — with tests in humans farther down the line.
When applied to the mouse version of the LabPET II scanner, the calibration of 6 144 channels was performed in less than 15 min and showed a 47% improvement on the overall time resolution of the scanner, decreasing from 7 ns to 3.7 ns full width at half maximum (FWHM).
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Efforts to model Down syndrome in mice have been complicated by the fact that the mouse versions of the genes on human chromosome 21 are inconveniently scattered across three mouse chromosomes.
However, he cautions that so far, other compounds that block this pathway in mice haven't panned out in clinical trials, and he'd like to see further research with different mouse versions of fibrosis.
More than 300 drugs that helped treat mouse versions of Alzheimer's disease, for instance, have failed in people.
The most thoroughly studied of these drugs, rapamycin, has been shown to delay mouse versions of Alzheimer's disease and even slow normal age-related where-did-I-leave-the-car-keys memory decline.
The vaccine worked at shrinking similar mouse versions of breast and pancreatic tumors, but researchers from the University of Georgia and the Mayo Clinic said that it could be applied to other cancers, too, including colorectal and ovarian cancers and multiple myeloma.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com