Sentence examples for mouse ventral prostate from inspiring English sources
Recently, a transcriptional signature specific for AKT1 activation and subsequent mTOR inhibitor RAD001 treatment was identified in luminal epithelial cells of the mouse ventral prostate [ 40].
Our earlier experiments indicated that PC-3 prostate cancer cells inoculated orthotopically to nude mouse ventral prostate (Fig 1A) form tumors (Fig 1B) and develop lymph node metastases in a time-dependent manner (data not shown).
Transgenic mouse studies suggest that expression and function of HOXB13 is restricted to the mouse ventral prostate (Economides and Capecchi, 2003) where it is involved in controlling secretion of p12, a kazal-type protease inhibitor, and the spermine binding protein p25.
Mouse ventral prostates were lysed in RIPA buffer.
Total RNA (3 µg) was extracted from mouse ventral prostates and separated on 1% glyoxal/DMSO/agarose gels (Ambion Inc., Austin, TX) and hybridized to either a human MYC or mouse Nkx3.1 cDNA probe.
All mice developed PIN in the ventral prostate by 4 weeks (Figures 1 3).
Further, at 12 weeks of age after 7 weeks on the resveratrol diet, TRAMP mice showed reduced cellular proliferation in the dorsolateral and ventral prostate compared with control diet mice (Harper et al. 2007).
BERKO mice show high proliferation and high apoptosis in the epithelial cells of the ventral prostate 56, 57 and increased prostatic hyperplasia, 56, 58 indicating that ERβ1 is important for maintaining a normal prostate and for suppressing tumor growth.
Prostatic intraepithelial neoplasia development in these mice is restricted to the anterior mouse prostate lobes and is not found in the ventral prostate lobe.
As expected, focal expression of HA-TGF-β1(a) was particularly evident in the ventral prostate lobe in transgenic mice owing to the efficacy of ARR2PB induced expression in this region of murine prostate gland.
Decreased Nkx3.1 protein in Lo-MYC mice was also verified by western blotting of ventral prostate lysates (Figure 3J).
