Sentence examples for mouse ventral mesencephalon from inspiring English sources
In contrast, DAT gene transcripts are not detected in the mouse ventral mesencephalon until DA axons reach the target at about E15, suggesting that during ontogeny, DA synthesis, and high-affinity uptake develop asynchronously and in a non-correlated fashion [27].
In contrast, gene transcripts for the dopamine transporter are not detected in the mouse ventral mesencephalon until dopamine axons reach the target at about Day 15.
In our study, cultures of mouse ventral mesencephalon dopaminergic neurons were exposed to MPP+ doses that resulted in cell death of more than one-third of the population of tyrosine hydroxylase-immunopositive cells.
Interestingly, this report described stereotaxic injection of the complexes into the mouse ventral midbrain and lateral ventricle.
Pten KO mice showed an enlarged ventral mesencephalon, neuronal hypertophy and increased numbers of DA neurons.
To further explore this phenotype in our LRRK2 transgenic mice, primary midbrain cultures were prepared from the ventral mesencephalon of G2019S-LRRK2 transgenic mice (line 340) and their non-transgenic littermates.
The results showed significant upregulation of Lhx8 by approximately 12.82 fold in mouse ventral hindbrain, compared to ventral midbrain.
Besides, upon intranigral LPS injection, a strong microglial up-regulation of cleavage caspase-8 was detected in the ventral mesencephalon of Casp8 fl/fl mice, which was mostly abolished in Cre LysMCasp8 fl/fl mice.
Under control conditions, typical resting microglia were distributed over the ventral mesencephalon in both Casp8 fl/fl mice and Cre LysMCasp8 fl/fl mice (Fig. 4a, d).
Consequently, we analysed key proinflammatory cytokines including interleukin (IL) IL-1β, IL-6 and tumor necrosis factor-α (TNF-α) along with iNOS in the ventral mesencephalon from either Casp8 fl/fl mice or Cre Lys Cre LysMCasp8 fl/fl MCasp8 fl/fl mice 6 h after injection of 2 μg LPS.
Interestingly, significant caspase-8 cleavage was detected in viable activated microglia in the ventral mesencephalon in Casp8 fl/fl mice in response to either intranigral LPS or MPTP.
