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In juveniles (PND22 23), USV monitoring upon exposure to an anesthetized female intruder mouse uncovered a clear genotype effect with reduced USV in Nlgn4−/− mice, and again a more prominent phenotype in females.
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Although cellular differentiation processes had long been considered unidirectional and irreversible, a set of experiments in mice uncovered a high developmental plasticity of hematopoietic cells.
Our microarray analysis of HS in the livers of mice uncovered a dramatic influence of PPARα on the overall gene expression pattern.
This approach, in conjunction with analysis of Bmi-1-KO mice and aged wild-type (WT) mice, uncovered a novel function of the Bmi-1/p16Ink4a Bmi-1/p16Ink4aliferation control of stem or pathwaytor cells in the submandibular glands (SMGs), which secrete saliva into the oral cavity (Young & van Lenneproliferation
Analysis of APP/APLP2 double knockout (dKO) mice uncovered an essential role for the APP and APLP2 in the patterning of neuromuscular junction (NMJ) [29], [30], [31].
Finally, our detailed examination of prostate morphology in Lo-MYC (and Hi-MYC) mice uncovered an additional intermediate step (cribriform PIN/CIS) in progression from mouse PIN to invasive carcinoma.
Our combined analysis of dSILAC and ribosome footprinting data from phenotypically affected tissues of Dnmt2−/− mice uncovered an additional function of Dnmt2 in the regulation of polypeptide synthesis.
A hypomorphic ATF2 mouse mutant uncovered a variety of developmental abnormalities, leading to defects in endochondral ossification as well as defects in the nervous system.
By comparing E2F4 DNA-binding events among multiple primary tissues in human and mouse, we uncovered a conserved set of regulatory interactions potentially relevant to maintaining cellular quiescence.
Recently, a localization study on endogenous mouse ZNF250/Zfp647 uncovered a novel type of nucleoplasmic body containing KRAB-ZNF proteins and TRIM28 in differentiated cells [ 91].
Studies in both Drosophila and mouse have uncovered a crucial role for Tudor domain-containing proteins in germline development and polar granules architecture (100– 100).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com