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This discordance may reflect the greater frequency at which mouse tumors develop from alveolar structures [ 33] compared to those of the human breast that often arise from less-differentiated TDLU-1 and -2 [ 17].
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Previous studies have shown that when MCF10DCIS cells are injected into the mammary fat-pad of immunodeficient nude (nu/nu) mice, tumors develop within 2 3 weeks.
In three of five controls and in six of six 5αP-treated mice, tumors developed.
In p27-/ mice, tumors developed in the lung, intestine, pituitary, ovary, and endometrium earlier and at a higher frequency as compared to both p27+/- and p27+/+ mice.
When YB-1 is overexpressed in the mammary gland of transgenic mice, breast tumors develop in all of mice [ 15].
The above experiments indicated that IGF2 expression showed significant discrimination ability for mouse liver tumors developed in cirrhotic and non-cirrhotic backgrounds.
While introduction of Kras and Akt led to glioma formation in Ntv-a mice, no tumors developed from the same combination in Gtv-a mice [20].
After cell injections into nude mice, HSA tumors developed from 4 cell lines.
When IGFBP2 was co-delivered with Akt to Ntv-a mice, no tumors developed, suggesting that IGFBP2 and Akt may lie in the same pathway [21].
The technique for developing monoclonal antibodies was developed by Drs. Georges Kohler and Cesar Milstein, using a mouse tumor line developed by NIH.
In 2008, the National Toxicology Program, part of the National Institutes of Health, released a report detailing how cancerous tumors developed in mice and rats that drank heavy doses of chromium-6.
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