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Mouse tryptases differ substantially in sequence, structure and distribution from those in humans 1 and mice lack α-tryptase 23, but it is of interest that the tryptases reside in a region that was one of the three that was identified in a genome-wide study of loci in this species linked to hyperresponsiveness to methacholine 50.
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Why do these mouse models differ?
Mouse strains differ in their susceptibility to stroke-induced immunosuppression.
Sunderkotter, C. et al. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response.
The histologic appearance of the prostates from probasin-bcl-2 transgenic mice or bax-/ mice did not differ from those of control littermates.
Resveratrol-injected and dihydroresveratrol-injected mice did not differ from AL-control mice (p = 0.147 and 0.764, respectively, Fig. 2).
Sensitivity to noxious heat of homozygous σ1R knockout mice did not differ from wild-type mice.
TPH2KO mice did not differ significantly from WT mice in peripheral 5-HT levels.
In contrast, circadian rhythms in SCN explants from Per3−/− mice do not differ from Per3+/+ mice.
The physical and social environment and behaviour of wild mice differ greatly from those of laboratory mice.
Our established Tax transgenic mice differ in several respects from these other transgenic mice.
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