Sentence examples for mouse transplantation model from inspiring English sources

Its mechanism could be due to the inhibition of T cell proliferation and, simultaneously, the promotion of the differentiation of TH0 to TH2 cells, thereby reducing GVHD in the mouse transplantation model.

We report here the effects of post transplant administration of AMD3100 on animal survival and on donor cell engraftment in a mouse transplantation model.

We examined the efficacy of post transplant administration of a specific CXCR4 antagonist (AMD3100) in improving animal survival and in enhancing donor hematopoietic cell engraftment using a congeneic mouse transplantation model.

These results suggested that Peptide 1 was able to inhibit the growth and dissemination of ovarian cancer cells in this mouse transplantation model.

The first in vivo demonstration was in AML, where only one cell in 250 000 could initiate disease in an immunocompromised SCID mouse transplantation model [ 19].

However, a recent study from Nagahama et al. reported conflicting findings in a minor histocompatibility antigen-mismatched mouse transplantation model 48.

Applying mouse transplantation models, we have demonstrated up to 100% survival of both heparanase treated and heparanase over-expressing mice, likely attributed not just to the above described improved engraftment, but primarily to a marked suppression of GVHD.

We investigated this possibility using both subcutaneous and intracranial mouse transplantation models.

For instance, OB-specific activation of the parathyroid hormone receptor and subsequent secretion of TGF- β reduced LSCs in CML but increased LSC numbers in MLL/AF9-induced AML in mouse transplantation models.

One of the emphases of this study is that we did not use severe combined immunodeficiency mice-transplantation model, but used MLL AFF1 Tg mice model whose immune systems are basically normal.

In a mouse BM transplantation model, combined 6TG preconditioning and in vivo chemoselection consistently achieved >95% engraftment of HPRT-deficient donor BM and long-term reconstitution of histologically and immunophenotypically normal hematopoiesis in both primary and secondary recipients, without significant toxicity and in the absence of any other cytotoxic conditioning regimen.