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To investigate the consequences of increased mitochondrial oxidative stress in the context of an established mouse model of AD, we crossed the Tg2576 mouse to mice heterozygous for sod2, a model of mild mitochondrial oxidative stress [9], [51], [52].
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These changes could be induced by the diameter of the needles in the syringes used for the mouse to mouse transfer of the cysts.
Since the time points of blood sampling and plasma glucose measurements varied slightly from mouse to mouse, interpolation was applied for the inter-group analysis at predefined time points.
Interestingly, the phenotype of Smad7liver-KO mice varied from mouse to mouse.
As for IgG, mouse to mouse variability in the IgM response was also observed.
The amount of antibody produced varied from mouse to mouse and did not depend on the amount of injected protein.
The period of these oscillation differed from mouse to mouse, but the oscillatory periods were quite similar among islets from the same mouse, which indicates imprinting.
Immediately thereafter, the cells were concentrated, treated with a lethal dose of X-rays and delivered by perilesional injection (2 × 10 per mouse) to mice-bearing established SCCVII tumours.
They were subsequently transplanted from mouse to mouse.
The percent of mosaicism varies from mouse to mouse, and among tissues in the same mouse.
At that time point mouse to mouse variation in T-cell response can be expected.
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