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Comparison of mouse to human impact on cellular senescence in the colon.
The low number of patients in our pilot analysis and the fact that there might be mouse to human differences in macrophage function limits the conclusions of our study on the human relevance of our findings.
I must say that we need to be careful not to be overly speculative because making the leap from a mouse to human in this specific case is difficult.
Alternatively, the difference could reflect mouse to human differences in native Ab clearance kinetics.
Vaccine-induced memory CD8+ T cells provide clinical benefit in HER2 expressing breast cancer: a mouse to human translational study.
Importantly, CAR exhibits remarkable species selectivity in its ligand binding and activation profiles, which makes direct extrapolation of findings from mouse to human extremely risky.
The main concern in repeated cell injections is a possible immune response after the first exposure of the mouse to human cells.
Spontaneously beating cells are rare, indicating that more work is required to translate findings from the mouse to human and uncover undiscovered molecular barriers in human reprogramming.
It is now shown that a large binding site for a protein antigen (lysozyme) can also be transplanted from mouse to human heavy chain.
Look for progress in translating results from mouse to human ES cells as governments around the world clarify their rules and more scientists gain access to the human cell lines.
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In mental health, obesity, and some subsets of oncology, the mouse-to-human translation is fraught with uncertainty.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com