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In the present report, we have used the Vβ12-tg mouse to establish a system where it is possible to track T cells specific for galactosylated CII peptide.
In general, two to three ablation-induced thrombi were allowed to form in each mouse to establish human platelet incorporation parameters without ReoPro.
Then 3 × 10 pCIS-A549 cells were injected subcutaneously into each nude mouse on the right axilla and the same number of control A549 cells on the contralateral axillary regions of the same mouse to establish a xenograft tumor model.
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BALB/c nude mice were chosen for these experiments since in vivo models for radionuclide therapy require immunodeficient mice to establish human tumor xenografts.
The homogeneous CD133+CXCR4+ CSC was transplanted with the scaffold into the pancreas of nude mice to establish a metastatic pancreatic tumor.
This time was enough for the mice to establish a hierarchy.
CT26 cells were transplanted to syngeneic mice to establish lung metastases.
Founder mice were bred with C57BL/6J mice to establish "pBI-cAMP" transgenic lines expressing the F46L-variant of the original cAMP reporter.
We then combined the number of MKP present in the BM and spleen in SHIP deficient mice to establish the total MKP body number.
Since homozygous Pkd1 and Kif3a null mice are embryonic lethal [32], [39], [40], we examined compound heterozygous Pkd1 and Kif3a deficient mice to establish a potential functional link between Pkd1 and Kif3a.
Here, we examined primary CD8 T cell responses following i.v. and oral gavage infection of C57BL/6 mice to establish a model examining the initiation of adaptive immunity to Listeria.
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