We show that SIRT1-ΔExon8 is expressed widely throughout normal human and mouse tissues, suggesting evolutionary conservation and critical function.
Because every primary tissue contains different sets of transcription factors, chromatin remodelers, and, indeed, chromatin structures, the presence of a commonly bound set of genes that makes up the large majority of E2F4 binding targets in multiple human (or mouse) tissues suggests that this key member of the DREAM complex binds independently of the above factors.
Interestingly, we detected higher levels of ΔNp73 in some mouse tissues, suggesting that ΔNp73 may have a physiological role in these tissues.
SMARCAL1 transcripts are ubiquitously expressed in different human and mouse tissues, suggesting a role in normal cellular functions or housekeeping activities, such as transcriptional regulation [ 21].
Of these, six genes (Creg1, Ctsc, Enpp1, Gstm4 Pdk1 and Sqrdl) were detected in mouse tissues, suggesting the other 43 genes may contribute to rat-specific events.
In fact, several individual E2F-specific targets were reported in cultured cells and mouse tissues, suggesting that each E2F protein has a cell type-specific biologically distinct role.
Curcumin also elevates the protein as well as mRNA expressions of GSTs and NQO1 in mouse tissues, suggesting a role of curcumin in transcriptional regulation of phase II enzymes [ 77].
Taken together, data obtained from both mouse and human tissues suggest that hepatocytic differentiation is accompanied by a transition from an EpCAM-positive to an EpCAM-negative state of cells, which mostly recapitulates essential stages of embryonic hepatogenesis.
Identification of a relatively high fraction of genes commonly regulated by Pax6 between two distinct mouse embryonic tissues suggests that Pax6 participates in similar regulatory events during both lens and forebrain development.
A single study reported that CR prevented the age-dependent increase of miR-181a-1 miR-181a-1 miR-181a-1 along with the reciprocal up-regulation of their target Bcl-2 gene in mouse brain tissues, suggesting that CR decreased apoptosis and induced a gain in neuronal survival [ 44].
