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These data indicate that in the Ildr1 w−/− mouse there is an early postnatal loss of OHC function.
In mouse there is just one copy of HS1.2 that constantly harbors a single copy of the 40 mer.
In mouse there is redundancy in this family, and Lhx5 is specifically required for hippocampal neurogenesis and migration [ 46].
In the TGF-β1 knockout mouse there is an increase in mitochondrial membrane potential, and such increases are associated with initiation of apoptosis.
However, one must remember that in the 11β-HSD2−/− mouse there is no 11β-HSD1 substrate (11-dehydrocorticosterone) and therefore this will have ramifications for brain function, albeit perhaps most notably with ageing.
It has been earlier reported in an S6k1−/− mouse there is an increase in life span by activation of AMPK and increased resistance against many age related diseases but no effect on age-related increase in cancer incidence [ 4].
Similar(29)
In mouse there are 652 regions with a p-value p RNAcode <0.01.
In activin transgenic mice there is apparently no effect on neurogenesis [ 57], although i.c.v.
In mice there are about 1,800 glomeruli on each side of the brain, in rabbits there are about 2,000, and in dogs there are as many as 5,000.
In mice there are two Pot1 genes, Pot1a and Pot1b.
I think it's constant game of cat and mouse – there's no winner.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com