As both zygote donors and mice used for founder segregation (or single transgenic mouse production) were all B6/CBA F1 mice, the overall genetic background for all the littermates were the same.
While surprisingly the DNA damage response (formation of repair foci, chromosomal breakage, and G2/M checkpoint function after irradiation) appears to be largely normal in cell cultures derived from Mcph1gt/gt mice, the overall survival rates of the Mcph1gt/gt animals are significantly reduced compared to wild type and heterozygous mice.
We demonstrated that, at least in young mice, the overall effect of FGF2 in the joint is benign.
In the susceptible group of CCBAF2 mice the overall distribution of genotypes at SNP 4_80 were not significantly different from the expected Mendelian ratios.
In both rats and mice, the overall density of labeled vessels was essentially the same following LPS treatment as in controls.
In adult mice, the overall production of insulin is not altered in Rfx6ΔBeta islets and thus Rfx6 is not indispensible for insulin production in β cells.
When compared with wild-type mice, the overall brain size and weight of ku70 −/− mice were smaller whereas bax −/− brains were larger, and the number of hippocampal neurons showed a similar trend (Supplementary Figure S8A).
Although levels of collagen were somewhat lower in CpG ODN-treated mice than in control mice, the overall levels of fibrosis were so low that meaningful interpretations of the data were not possible.
Although a similar pattern of staining were seen in the hippocampus of the wild-type mice, the overall staining was much lighter than that found in the rTg4510 model.
At 12 months, 53% of CAG140 KI cells responded with an increase in EPSC frequency and, similarly to the oldest group in the YAC128 mice, the overall effect of BIC did not reach statistical significance (P = 0.06).
